About

Leveraging human genetics and multiomics data to gain insights on drug targets and their safety.

• Applied a genetics-first approach for novel drug target discovery, risk assessment, and indication expansion
• Presented genetic findings and strategic recommendations to stakeholders at partner pharma and biotech companies
• Performed fine-mapping of complex genetic signals to pinpoint causal variants across multiple diseases
• Analyzed evidence from both rare and common variants using methods like colocalization and Mendelian randomization

Development of a similarity-based gene prioritisation method.

• Continuation and expansion of the work started during the RiSE studentship
• Benchmarking against other similarity-based methods (e.g. PoPS)
• Implementation in a python package, CLI tool and Nextflow pipeline used internally

Development of a similarity-based gene prioritisation method.

• RiSE studentship in the neurogenomics team (Pharma Research and Early Development (pRED))
• Development of a similarity-based machine learning method for risk gene prioritisation from GWAS summary statistics

Software maintenance and development at the Bank of France.

• Development and maintenance of a legacy codebase
• Promoting better coding practices within the team: clean code, TDD, and initiation of regular internal tech meetings

Development and benchmarking of a CNV detection pipeline in exome sequencing data

• Master’s thesis project completed at Sophia Genetics
• Worked on the application of the internal CNV calling algorithm to clinical exome data
• Benchmarking against existing methods XHMM and CoNIFER

Digital Epidemiology Lab - Prof. Marcel Salathé

• Exploration of application of deep learning to genetic data
• Helped prepare genetic datasets for OpenSNP height prediction challenge on AI Crowd platform

Internship at the Biology of Infection Unit - Prof. Marc Lecuit

• Study of the hepatic response to Listeria monocytogenes.
• Experiments in sterile environment and in A3 animal facilities.
• Contribution to research plan elaboration and communication with a multidisciplinary team.
• Contributed to findings published in an original research paper .